Rai... sed in Bridgewater, Nova Scotia, he took an early interest in the entertainment industry, becoming a radio DJ by the time he was fourteen. While an engineering student at the University of Toronto, he discovered his love for acting and duly decided to pursue theatrical training. An attempt to enroll at the London Academy of Music and Dramatic Art was thwarted, however, because of his size (6'4") and idiosyncratic looks. Not one to give up, Sutherland began doing British repertory theatre and getting acting stints on television series like The Saint.

In 1964 the actor got his first big break, making his screen debut in the Italian horror film Il Castello dei Morti Vivi (The Castle of the Living Dead). His dual role as a young soldier and an old hag was enough to convince various casting directors of a certain kind of versatility, and Sutherland was soon appearing in a number of remarkably schlocky films, including Dr. Terror's House of Horrors and Die! Die! Darling! (both 1965). A move into more respectable fare came in 1967, when Robert Aldrich cast him as a retarded killer in the highly successful The Dirty Dozen.

By the early '70s, Sutherland had become something of a bonafide star, thanks to lead roles in films like Start the Revolution without Me and Robert Altman's MASH (both 1970). It was his role as Army surgeon Hawkeye Pierce in the latter film that gave the actor particular respect and credibility, and the following year he enhanced his reputation with a portrayal of the titular private detective in Alan J. Pakula's Klute. It was during this period that Sutherland became something of an idol for a younger, counter culture audience, due to both the kind of roles he took and his own anti-war stance.

Offscreen, he spent a great deal of time protesting the Vietnam War, and, with the participation of fellow protestor and Klute co-star Jane Fonda, made the anti-war documentary F.T.A. in 1972.

He also continued his mainstream Hollywood work, enjoying success with films like Don't Look Now (1973), The Day of the Locust (1975), and Fellini's Casanova (1976). In 1978, he won a permanent place in the hearts and minds of slackers everywhere with his portrayal of a pot-smoking, metaphysics-spouting college professor in National Lampoon's Animal House. After a starring role in the critically acclaimed Ordinary People (1980), Sutherland entered a relatively unremarkable phase of his career, appearing in one forgettable film after another. This phase continued for much of the decade, and didn't begin to change until 1989, when the actor won raves for his starring role in A Dry White Season and his title role in Bethune: The Making of a Hero.

He spent the 1990s doing steady work in films of widely varying quality, appearing as the informant who cried conspiracy in JFK (1991), a Van Helsing-type figure in Buffy The Vampire Slayer (1992), a wealthy New Yorker who gets taken in by con artist Will Smith in Six Degrees of Separation (1993), and a general in the virus thriller Outbreak (1995). In 1998, the actor did some of his best work in years (in addition to the made-for-TV Citizen X (1995), for which he won an Emmy and a Golden Globe) when he starred as a track coach in Without Limits, Robert Towne's biopic of runner Steve Prefontaine. In 2000, Sutherland enjoyed further critical and commerical success with Space Cowboys, an adventure drama that teamed the actor alongside Tommy Lee Jones, Clint Eastwood, and James Garner as geriatric astronauts who get another chance to blast into orbit. Sutherland didn't pause as the new millennium began, continuing to contribute to several projects a year.

He won a Golden Globe for his performance in the 2003 Vietnam era HBO film Path to War, and over the next few years appeared in high-profile films such as The Italian Job, Cold Mountain, and Pride and Prejudice, while continuing to spend time on smaller projects, like 2005's Aurora Borealis. The next year, Sutherland appeared with Mira Sorvino in the TV movie Human Trafficking, which tackled the frightening subject matter of modern day sexual slave trade. He also joined the cast of the new ABC series Commander in Chief, starring Geena Davis as the American vice president who assumes the role of commander in chief when the president dies. Sutherland's role as one of the old boys who is none too pleased to see a woman in the Oval Office earned him a Golden Globe nomination in 2006, as did his performance in Human Trafficking. In 2006, Sutherland worked with Collin Farrell and Salma Hayek in one of screenwriter Robert Towne's rare ventures into film direction with Ask the Dust. Sutherland has also earned a different sort of recognition for his real-life role as the father of actor and sometimes tabloid fodder Kiefer Sutherland. The elder Sutherland named his son after producer Warren Kiefer, who gave him his first big break by casting him in Il Castello dei Morti Vivi.